Primary brain tumours, especially high-grade glioma, are among the most debilitating and morbid of diagnoses. Patients are often given poor prognoses (i.e. 12- 15 months survival) and suffer a range of symptoms during treatment, including; depression, fatigue, poor physical functioning and cognitive decline. It is therefore paramount that interventions are focused not only on longevity, but on optimizing quality of life. The current research project aims to better elucidate one such intervention, physical activity. Physical activity has been shown to improve survival and quality of life in a variety of diseases and cancers, though evidence for primary brain tumour remains to be well described. The current project is a prospective evaluation of physical activity levels in primary brain tumour patients. We will evaluate the level of physical activity, quality of life and degree of fatigue, depression and functional status at the time of diagnosis and each month thereafter for 6-months.

The goals of the project are threefold. We will better elucidate the link between physical activity level and quality of life at discrete time points. We will investigate the link between physical activity level at discrete time points and 6-month progression free survival. Finally, the unique 6-month follow-up period will allow for an investigation into the temporal dynamics of both physical activity participation and quality of life during the disease course. It is hypothesized that individual who more routinely participate in physical activity will describe greater quality of life and 6-month progression free survival than those who do not.