Previous studies have shown that nurses working in hospitals during pandemics may face significant stress due to concerns about their own and their families’ health and safety, high patient mortality rates, ethical challenges associated with patient care and perceived unsafe working conditions. However, the unique experiences of RNs working in border cities and facing different health care systems with different responses to the COVID-19 pandemic is unknown. The purpose of this investigation is to explore Windsor RNs’ experiences of working in hospitals on both sides of the border during the pandemic through in-depth interviews. Results will allow us to identify significant mental health challenges and find ways to support their recovery and resilience during and after the crisis.